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Single Donor Platelets
Definition:
A component obtained by platelet apheresis of a single donor using automated
cell separation equipment.
Properties:
Depending on method and equipment used, each procedure should give a
platelet yield from 200 to 800 x 109. Leucocytes and red cells should
also be minimal although much depends on method an equipment used. SDP
provides the advantage of collecting platelets from selected donors,
to reduce risk of HLA alloimmunisation and for effective treatment of
patients already alloimmunised. Reducing the number of donor exposures
also reduces risks of viral transmisson.
Methods
of preparation: Platelets extracted directly from the donor
using an apheresis equipment. This involves the donor having to stay
hooked to this equipment for about 2 hours to produce good quality platelets
which would still need to be further processed for better quality.
Storage
& Stability: Platelets must be stored in plastic bags intended
for platelet storage having the characteristic of being permeable to
gases for oxygen availability for platelets. During storage pH must
remain between 6.8 to 7.4 and they must be continuously agitated in
an appropriate equipment, with a temperature of between +20 degrees
celcius to +24 degrees celcius. Platelets under the above parameters
can be stored for 5 days.